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In Korea, vigabatrin dosage form is only 500㎎ tablet. But children´s doses are small, we cannot use it directly to children. We should crush it and packaged it with vinyl films for patients use. If we crush tablet to powder form, we should know about stability test result of vigabatrin powder dosage form. But we dont have stability results. We studied about stability of vigabatrin powdered form. We did two kinds of studies. One condition is light shield. We powdered vigabatrin and packaged it with vinyl films and inserted into light-shield package, and the others ate packaged without light-shield envelope. Powdered vigabatrin contents are not changed for 11 weeks. The results are 85∼110% contents, but the contents at 12 week is 60%. We should study about this result. Second conditions related temperature such as high temperature (37℃), room temperature (24∼30℃), cool temperature (4℃). The results are as follows. At high temperature condition, the content of vigabatrin at 12 weeks is 88.7%, room temperature 85.9%, cool temperature 86.4%. So we conclude that vigabatrin powder does not lose its strength from roomlight, high temperature, room temperature, cool temperature for 12 weeks.
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